Association between the cumulative atherogenic index of plasma and cardiometabolic multimorbidity: the mediating effects of the TyG index and body mass index.

ABSTRACT:

Background

Cardiometabolic multimorbidity (CMM) poses a significant global health challenge. The atherogenic index of plasma (AIP) is a promising biomarker for cardiometabolic risk, but there is limited information on its cumulative effect on CMM and the underlying mechanisms. This study investigated the association of cumulative AIP exposure with CMM risk, and explored the mediating roles of the triglyceride glucose (TyG) index and body mass index (BMI).

Methods

This study was based on data from 5,454 participants from the China Health and Retirement Longitudinal Study (CHARLS, 2011 baseline). The participants were stratified into tertiles of cumulative AIP (cuAIP) and classified into three distinct AIP trajectory groups using k-means clustering. Associations between cuAIP

SUBMITTER: He Q 

PROVIDER: S-EPMC12924325 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature