Dataset Information
Nucleocapsid protein enhances spike- and RBD-specific humoral and cellular immune responses in protein-based SARS-CoV-2 vaccine.
Ontology highlight
ABSTRACT:
SUBMITTER: Grohn S
PROVIDER: S-EPMC12924367 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
Nucleocapsid protein enhances spike- and RBD-specific humoral and cellular immune responses in protein-based SARS-CoV-2 vaccine.
BMC infectious diseases 20260129 1
BACKGROUND: Current COVID-19 vaccines are effective at preventing severe disease but provide limited protection against infection and transmission, particularly as new variants emerge. Vaccines capable of inducing both systemic and mucosal immunity and robust T cell responses, may offer broader and more long-lasting protection. This study aimed to evaluate protein-based vaccine candidates incorporating SARS-CoV-2 spike (S) and its receptor-binding domain (RBD), as well as nucleocapsid protein (N ...[more]