Lung function as a mediator: bridging appendicular skeletal muscle mass and dementia in middle-aged and older Chinese adults.

ABSTRACT:

Background

The link between appendicular skeletal muscle mass (ASM) and dementia remains unclear. This study investigates whether lung function (LF) mediates the relationship between ASM and dementia in both cross-sectional and longitudinal analyses.

Methods

This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) collected between 2011 and 2018, involving 8,391 participants for cross-sectional and 5,053 for longitudinal analysis. Multivariate logistic regression and Cox proportional hazards models evaluated the links between ASM, LF, and dementia risk. Nonlinear dose-response relationships were assessed with restricted cubic spline (RCS) analysis, and subgroup analyses examined demographic differences. The R package mediation was used for ca

SUBMITTER: Ding H 

PROVIDER: S-EPMC12924395 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature