Dataset Information
Effects of vatinoxan and fentanyl on blood glucose concentrations and diuresis in male Wistar rats sedated with medetomidine and midazolam.
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ABSTRACT:
SUBMITTER: Lindh E
PROVIDER: S-EPMC12924401 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
Effects of vatinoxan and fentanyl on blood glucose concentrations and diuresis in male Wistar rats sedated with medetomidine and midazolam.
BMC veterinary research 20260129 1
BACKGROUND: Alpha2-adrenoceptor agonists such as medetomidine induce hyperglycemia, glucosuria, and polyuria. We evaluated the ability of vatinoxan, a peripherally acting alpha2-adrenoceptor antagonist, to mitigate these side effects in male Wistar rats (N = 31). To explore its impact on two common sedation protocols in laboratory rats, a randomized, controlled experimental study was conducted comprising four groups: medetomidine (0.25 mg/kg) and midazolam (2.0 mg/kg) (MM; N = 8), MM + fentanyl ...[more]
