Association of severe depression with bone mineral content: a mediation analysis in PERSIAN cohort study.

ABSTRACT:

Background

Depression may lead to lower Bone Mineral Content (BMC), as an indicator of bone health. In this study, we aim to estimate the direct, indirect, and total associations of depression with BMC through various mediators to explain the mechanism behind the reduction in BMC.

Methods

This is a cross-sectional study within the PERSIAN perspective cohort study at Mashhad University of Medical Sciences (MUMS) in northeastern Iran, involving 3179 personnel in 2019-2020. Depression was assessed using the standard DASS-21 questionnaire. Smoking, taking sleeping pills, falling asleep duration, and metabolic equivalents (METs) served as mediators, based on the literature review. We employed mediation analysis packages, with a counterfactual approach, to estimate the various ass

SUBMITTER: Sahebi M 

PROVIDER: S-EPMC12924434 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature