Synergistic chemodynamic-photothermal therapy of super-resistant Enterobacter asburiae-infected sepsis using multifunctional mesoporous nanocomposite.

ABSTRACT: Multidrug-resistant bacterial infections pose a severe threat to sepsis, where uncontrolled bacterial proliferation and the accompanying inflammatory response lead to multiorgan dysfunction. Recent clinical isolation of a super-resistant Enterobacter asburiae (E. asburiae) strain co-harboring mcr-10 and bla_NDM-1 underscores the urgent need for more effective antimicrobial strategies. Herein, we develop a synergistic strategy for the chemodynamic and photothermal therapy of super-resistant E. asburiae using a multifunctional mesoporous nanocomposite. This nanocomposite is composed of mesoporous silica nanoparticle loaded with polymyxin B, polydopamine, and palladium nanoparticles, possessing properties including photothermal therapy, chemodynamic therapy, and drug cargo. This syn

SUBMITTER: Zou A 

PROVIDER: S-EPMC12924451 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature