Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case-control study nested in the French E3N-Generations cohort.

ABSTRACT:

Background

Air pollution is a complex mixture of closely correlated pollutants, making it challenging to assess both the overall mixture effect and to isolate the individual impact of each pollutant on breast cancer (BC) risk. This study assessed the effect of exposure to a mixture of seven correlated air pollutants (benzo[a]pyrene, cadmium, dioxins, polychlorinated biphenyl 153 (PCB153), nitrogen dioxide (NO₂), particulate matter (PM_2.5 and PM₁₀)) on BC risk.

Methods

The study was based on a case-control study nested within the French E3N-Generations cohort (5222 incident BC cases/5222 matched controls). Annual average concentrations of each pollutant were estimated using the CHIMERE chemistry-transport model, based on participants' resident

SUBMITTER: Giampiccolo C 

PROVIDER: S-EPMC12924484 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature