Association of metal exposure in follicular fluid with assisted reproductive technology outcomes in East Chinese women.

ABSTRACT:

Background

An increasing body of evidence indicates that exposure to metal elements may adversely affect female fertility. While the association between metal concentrations in the follicular fluid (FF) and fertility is acknowledged, the relationship between metal exposure in FF and the outcomes of assisted reproductive technology (ART) remains ambiguous.

Methods

We quantified eight metals in FF from 139 reproductive-age women in China using a trace element analyzer. To assess their relationships with critical ART metrics, logistic regression, stratified analysis based on age and body mass index (BMI) were used. Additionally, restricted cubic splines (RCS) were applied to examine potential nonlinear relationships between metal concentrations and outcomes, and Bayesian kernel

SUBMITTER: Han Y 

PROVIDER: S-EPMC12924500 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature