Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial.

ABSTRACT:

Background

The aim of this secondary analysis of the BENEFIT randomized controlled trial was to investigate the effects of aerobic training (AT) or resistance training (RT) during neoadjuvant chemotherapy (NACT) on sleep and cancer-related fatigue (CRF), compared to a waitlist control group (WCG) that performed RT after surgery.

Methods

In the BENEFIT study, 184 patients with breast cancer with scheduled NACT (mean age = 50 years, standard deviation = 11) were randomized to AT (n = 62), RT (n = 62), or WCG (n = 60). While the AT and RT groups trained during NACT (two supervised and one home-based session weekly), the WCG completed the same training as the RT group but only after breast surgery. Self-reported sleep quality (Pittsburgh Sleep Quality Index) and CRF (EORTC QLQ-F

SUBMITTER: Haussmann A 

PROVIDER: S-EPMC12924517 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature