Development of an integrated risk stratification model for metastatic medulloblastoma (M2/3) using clinical, radiologic, and molecular variables.

ABSTRACT:

Background

Approximately 20% of medulloblastoma (MB) patients are diagnosed with metastatic disease and typically exhibit extremely poor clinical outcomes. This study aimed to investigate potential prognostic factors affecting the survival of patients with metastatic MB.

Methods

Patients with initial diagnosis of metastatic MB (M2/3) at Beijing Tiantan Hospital were included. Radiological characteristics were discerned through a retrospective review. Overall survival (OS) and event-free survival (EFS) were calculated using the Kaplan-Meier analysis. Multivariable Cox proportional hazards model was employed to identify potential prognostic factors.

Results

This study included 115 patients with M2/3 MB. Group 4 MBs accounted for 59.1% of cases (68/115). Kaplan-Meier ana

SUBMITTER: Zhou WT 

PROVIDER: S-EPMC12924635 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature