Highly Excretable Gold Supraclusters for Translatable <i>In Vivo</i> Raman Imaging of Tumors.

ABSTRACT: Raman spectroscopy provides excellent specificity for in vivo preclinical imaging through a readout of fingerprint-like spectra. To achieve sufficient sensitivity for in vivo Raman imaging, metallic gold nanoparticles larger than 10 nm were employed to amplify Raman signals via surface-enhanced Raman scattering (SERS). However, the inability to excrete such large gold nanoparticles has restricted the translation of Raman imaging. Here we present Raman-active metallic gold supraclusters that are biodegradable and excretable as nanoclusters. Although the small size of the gold nanocluster building blocks compromises the electromagnetic field enhancement effect, the supraclusters exhibit bright and prominent Raman scattering comparable to that of large gold nanoparticle-based SE

SUBMITTER: Yu JH 

PROVIDER: S-EPMC12924649 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature