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ABSTRACT: Objectives
To develop a non-toxic, probiotic-infused activated charcoal/hydroxyapatite microbeads (PIMD) formulated with activated charcoal and hydroxyapatite. The formulation is designed to establish a stable probiotic biofilm on high-risk surfaces, such as medical sink basins and food cutting boards. Its dual mechanism aims to achieve rapid pathogen inhibition and long-term protection through sustained competitive exclusion, including against antibiotic-resistant microorganisms.Methods
An applied study was conducted in the Al-Baha region of Saudi Arabia (January 2021-May 2025) employing probiotic-based biotechnology to engineer spatially segregated microenvironments using activated charcoal-hydroxyapatite microbeads. The study integrated ecological modeling concepts-inclu
SUBMITTER: Alqumber MA
PROVIDER: S-EPMC12924655 | biostudies-literature | 2026
REPOSITORIES: biostudies-literature