Maternal adversity and peripheral proinflammatory cytokine concentrations in pregnancy.

ABSTRACT:

Background

Psychosocial stressors such as adverse childhood experiences (ACEs) and financial hardship have been linked to inflammatory phenotypes. Few studies have investigated the role of childhood and current stressors on inflammatory marker concentrations in pregnancy, a period marked by shifts in immune activity. This study examined the associations among ACEs, financial stress, and concentrations of three cytokines: TNF-α, IL-6, and IL-8 in pregnant people. Additionally, we explored whether current financial stress amplified relations between ACEs and immune activity, and, in contrast, whether current social support served as a potential buffer.

Methods

Pregnant people (n = 304) ages 18+ were enrolled from two prospective pregnancy cohorts in North Carolina and Florida

SUBMITTER: Sifnugel N 

PROVIDER: S-EPMC12924726 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature