Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates.

ABSTRACT:

Purpose

Glioblastoma is an aggressive primary brain tumor that often exhibits perivascular invasion. This behavior may directly interfere with glymphatic flow, hindering perivascular drainage routes. This study aims to assess glymphatic dysfunction in glioblastoma by evaluating the DTI-ALPS index, an MRI-based surrogate of glymphatic activity. We additionally correlate mpMRI-derived tumor features with radio-pathomic maps of hypercellularity.

Methods

We included 368 IDH-wildtype GBM patients from the UCSF-PDGM dataset. Preoperative T1, T1C, FLAIR, ADC, and diffusion tensor imaging (DTI) maps were preprocessed using standard co-registration and intensity normalization protocols. Radio-pathomic maps of tumor cellularity were generated using a previously published model which w

SUBMITTER: Nath B 

PROVIDER: S-EPMC12924826 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature