The Radioprotective Effects of (-)-Epigallocatechin-3-gallate (EGCG): Restoring the Gut Microbiota-Immune Axis to Ameliorate Radiation-Induced Intestinal Injury.

ABSTRACT:

Objectives

To investigate the protective effect and mechanism of (-)-epigallocatechin-3-gallate (EGCG) against radiation-induced intestinal injury (RIII).

Methods

C57BL/6J mice were pretreated with 10 mg/kg EGCG for 10 weeks or 3 days before 10 Gy total body irradiation (TBI) or whole abdominal irradiation (WAI), focusing on survival, body weight, intestinal structure, inflammation, and gut microbiota. For mechanism exploration, peritoneal and RAW264.7 macrophages were pretreated with 0-50 μM EGCG before irradiation, followed by assessments of cell viability, inflammatory proteins, and related signaling.

Results

EGCG protects mice from TBI-induced toxicity and weight loss, and alleviates WAI-induced intestinal injury, characterized by preserved villus architecture and

SUBMITTER: Gu J 

PROVIDER: S-EPMC12925019 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature