The VAX2-SERPINE1 axis modulates colorectal cancer cell proliferation and apoptosis through WNT/beta-catenin signaling.

ABSTRACT: Transcription factors (TFs) involve in colorectal cancer (CRC). However, the function and mechanism of VAX2 in the development of CRC remain barely known. In the present study, we observed that transcription factor VAX2 is frequently upregulated in CRC internal sample set and external tissue microarray and cell lines. High VAX2 expression is observably correlated with tumor invasiveness and AJCC stage of tumors in CRC. Furthermore, decreased expression of VAX2 functionally inhibits the proliferation and facilitates the apoptosis of CRC cells and vice versa. Mechanistically, VAX2 involves in WNT/beta-catenin signaling through facilitating the nucleus accumulation of beta-catenin and VAX2 specifically binds to the promoter and trigger the transcription of SERPINE1. SERPINE1 overexpression si

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12925055 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature