Bioactive Metabolites from <i>Lactobacillus acidophilus</i>-Fermented Products Mitigate Carbon Tetrachloride-Induced Liver Injury: Biochemical and In Silico Insights.

ABSTRACT:

Background

Fermented products derived from Lactobacillus have demonstrated therapeutic potential in the management of metabolic disorders, particularly liver diseases.

Objectives

This study aimed to evaluate the hepatoprotective effects of Lactobacillus-fermented products in a carbon tetrachloride (CCl₄)-induced murine model of liver damage, with a focus on analyzing the influence of bioactive compounds on key liver function biomarkers.

Methods

Two Lactobacillus strains (Lactobacillus acidophilus LB-CARS1 and L. acidophilus ST-CARS2) were isolated from commercial yogurts, and milk was fermented using each strain. A total of 40 male Swiss Albino mice were allocated into 5 experimental groups: control, CCl₄-only,

SUBMITTER: Islam MS 

PROVIDER: S-EPMC12925109 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature