IModMix: integrative module analysis for multi-omics data.

ABSTRACT:

Summary

Integrative Module Analysis for Multi-omics Data (iModMix) is a biology-agnostic framework that enables the discovery of novel associations across any type of quantitative abundance data, including but not limited to transcriptomics, proteomics, and metabolomics. Instead of relying on pathway annotations or prior biological knowledge, iModMix constructs data-driven modules using graphical lasso to estimate sparse networks from omics features. These modules are summarized into eigenfeatures and correlated across datasets for horizontal integration, while preserving the distinct feature sets and interpretability of each omics type. iModMix operates directly on matrices containing expression or abundances for a wide range of features, including but not limited to genes, protei

SUBMITTER: Narvaez-Bandera I 

PROVIDER: S-EPMC12925246 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature