PYRAMA: an open-source tool for advanced meta-analysis of genome wide association studies.

ABSTRACT:

Motivation

Genome-wide association study (GWAS) meta-analysis tools are essential for integrating summary statistics across multiple cohorts, thereby increasing statistical power and validating genetic associations. Widely cited tools, such as METAL, PLINK, and GWAMA, have facilitated numerous significant discoveries in the field of GWAS. Nevertheless, these tools offer a limited set of meta-analysis methods and typically require users to have prior experience with command-line tools to be executed.

Results

We present here PYRAMA, an open-source tool which is designed for meta-analysis of genome wide association studies. This work introduces an easy-to-use software package that includes several meta-analysis methods that are absent in similar software packages. PYRAMA is fas

SUBMITTER: Manios GA 

PROVIDER: S-EPMC12925247 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature