Environmentally activatable hydrogel for spatiotemporally programmed nitric oxide delivery for diabetic wound healing.

ABSTRACT: Nitric oxide (NO) plays a central role in wound healing, by regulating vascular homeostasis, inflammation, and antimicrobial effects. However, chronic diabetic wounds are difficult to heal due to the hyperglycemic microenvironment, which reduces endogenous NO production. Therefore, developing intelligent dressings capable of spatiotemporally programmed NO delivery holds great promise in promoting diabetic wound healing. Herein, we engineered an environmentally activatable hydrogel that enabled on-demand NO release for diabetic wound healing. The CS-SNAP hydrogel was achieved by covalent grafting of NO donor (S-nitroso-N-acetylpenicillamine, SNAP) onto the matrix of carboxymethyl chitosan methacryloyl (CMCSMA), and by subsequent fast photopolymerization during only 10 s. The CS-SNAP hydroge

SUBMITTER: Chai L 

PROVIDER: S-EPMC12925292 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature