Pauci-Immune Endocapillary Proliferative Glomerulonephritis With Glomerular M2 Macrophage Infiltration.

ABSTRACT:

Introduction

Pauci-immune endocapillary proliferative glomerulonephritis (GN) (Pauci-I-EPGN) is a rare glomerular disease with a heterogeneous and poorly understood etiology. Here we describe the clinicopathological features, immune cell infiltration patterns, and treatment outcomes of Pauci-I-EPGN.

Methods

Fifteen patients with biopsy-proven Pauci-I-EPGN, diagnosed between January 2012 and June 2025, were studied retrospectively.

Results

Fifteen patients (7 males and 8 females) aged 50.1 ±13.0 years at renal biopsy were included. The median 24 hour urine protein was 2.00 g/d (0.30-7.77 g/d), with a median serum creatinine level of 1.14 mg/dL (0.54-5.36 mg/dL). Seven cases had prodromal infection. Light microscopy (LM) showed endocapillary proliferative lesions in glo

SUBMITTER: Ma L 

PROVIDER: S-EPMC12925402 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature