Hormonal Modulation of Keratoconus: A Systematic Review and Screening Strategy for At-Risk Populations.

ABSTRACT:

Topic

Keratoconus (KCN) is a progressive corneal ectasia with poorly understood etiology and risk factors leading to inadequate screening methods for at-risk populations. One potentially vulnerable population includes individuals experiencing fluctuations in hypothalamic-pituitary-gonadal (HPG) axis hormones. This systematic review aims to evaluate the association between HPG-axis hormonal fluctuations and the development or progression of KCN.

Clinical relevance

Elucidating the relationship between HPG-axis hormone fluctuations and KCN may enhance screening strategies, facilitate early detection, and inform preventive measures in at-risk populations. Improved awareness among clinicians could lead to targeted monitoring and timely interventions.

Methods

A comprehensiv

SUBMITTER: Ashraf M 

PROVIDER: S-EPMC12925539 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature