Advances in ultrasound-activated nano-sonosensitizers for cancer treatment: a systematic review and meta-analysis.

ABSTRACT: Ultrasound (US)-activated nanotherapies represent a transformative frontier in oncology, leveraging the noninvasive deep penetration of acoustic energy for targeted tumor destruction. However, this field lacks a quantitative synthesis to guide the rational design of sono-sensitizing nanoparticles (NPs) and the optimization of therapeutic protocols. To address this issue, we performed a systematic review and meta-analysis of 144 recent research reports, establishing an evidence-based design hierarchy for nano-sonosensitizers. A meta-analysis of 86 in vitro studies revealed a profound synergistic reduction in cell viability when NPs were activated by US (pooled standard mean difference, SMD = -13.16, 95% CI [-14.67, -11.64], p < 0.001). NP size was the most influential design factor. Particl

SUBMITTER: Ayyami Y 

PROVIDER: S-EPMC12925597 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature