Inflammation, antiretroviral therapy continuation, and HIV disease progression in postpartum women with HIV.

ABSTRACT:

Background

Higher levels of inflammation are associated with increased HIV disease progression, but data are lacking in postpartum women with HIV (WHIV), who generally have a distinct immune profile. Further, the impact of discontinuation of antiretroviral therapy (ART) on inflammation is not well understood for postpartum women. We studied the relationship of ART discontinuation, inflammation, and HIV disease progression in postpartum WHIV.

Setting

We conducted a 1:3 case-control study (N=347) nested within a multi-country randomized trial comparing postpartum ART continuation vs. discontinuation in WHIV with WHO clinical stage 1 disease and who did not meet criteria for ART at the time. Median follow-up time was 97.1 weeks.

Methods

Cases were defined as WHIV who pro

SUBMITTER: Shivakoti R 

PROVIDER: S-EPMC12925601 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature