Genetic make-up and regulation of the L-lysine biosynthesis pathway in <i>Vibrio natriegens</i>.

ABSTRACT: Vibrio natriegens, the fastest growing non-pathogenic microorganism known to date, has emerged as a highly promising chassis strain for synthetic biology and biotechnology applications. This study analysed the make-up and regulation of the biosynthetic pathway for L-lysine and related L-aspartate family amino acids (AFAAs) in V. natriegens DSM759 to provide a comprehensive basis for future metabolic engineering endeavours aiming at developing this strain into an amino acid overproducer. The compilation of automatically annotated genome sequencing data revealed the presence of gene duplicates encoding putative isozymes for multiple enzymatic reactions within these pathways. The physiological role of these isozymes was analysed via growth phenotyping of corresponding gene delet

SUBMITTER: Straube E 

PROVIDER: S-EPMC12925634 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature