First multicenter Japanese registry on tissue proximity-guided pulsed field ablation: Procedural safety and mid-term outcomes.

ABSTRACT:

Background

Pulsed field ablation (PFA) is a novel therapy for atrial fibrillation (AF) with myocardial selectivity and safety. The VARIPULSE catheter (variable-loop circular catheter [VLCC]; Biosense Webster, Inc.) was recently introduced in Japan, but multicenter real-world data remain scarce.

Objective

This study aimed to evaluate procedural features, acute safety, and early outcomes of tissue proximity indication (TPI)-guided PFA under structured training and standardized protocols.

Methods

We retrospectively analyzed 387 consecutive patients with AF (66.4 ± 10.9 years, 69% male, 87.1% paroxysmal) undergoing initial pulmonary vein isolation (PVI) with the VLCC at 10 Japanese centers (April 2024-May 2025). TPI-guided first-pass PVI targeted ≥12 applications per vein

SUBMITTER: Sawada M 

PROVIDER: S-EPMC12925750 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature