Longitudinal 3D-DCE MRI Assessment of Placental Perfusion Under Reduced Uterine Perfusion Pressure in Pregnant Rats.

ABSTRACT: Placental insufficiency is a major cause of preeclampsia and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) rat model reproduces cardinal features of these disorders, but longitudinal changes in placental perfusion after RUPP are poorly documented. This study aimed to assess the acute and late effects of RUPP on placental perfusion between gestational day (GD) 14 and GD18 using 3D dynamic contrast-enhanced magnetic resonance imaging (3D-DCE MRI). Pregnant Sprague Dawley rats (n = 31) were randomized to RUPP or normal pregnant (NP) groups on GD14. 3D-DCE MRI scans were performed on GD14, GD15, and GD16 or GD18. Perfusion parameters, including time to peak (TTP), maximum enhancement (ME), wash-out percentage (WO%), initial area under the curve (iAUC), and total area

SUBMITTER: Al Darwish FM 

PROVIDER: S-EPMC12926275 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature