Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis.

ABSTRACT: Astrocytes from distinct hippocampal layers exhibit region-specific morphological traits, which may be influenced by their local microenvironment. During viral encephalitis, these cells undergo dynamic changes that can reflect layer-specific vulnerability. In this study, we characterized whether astrocytes from different CA3 hippocampal layers display distinct morphological responses to Piry virus-induced encephalitis. Adult female Swiss mice were intranasally inoculated with the Piry virus and sacrificed at 20- or 40-days post-infection (dpi). GFAP+ astrocytes from the Stratum lacunosum-moleculare (SLM) and Stratum oriens (SO) were three-dimensionally reconstructed. Morphometric data were evaluated using hierarchical clustering, linear discriminant analysis (LDA), and generalized linear m

SUBMITTER: de Almeida Miranda D 

PROVIDER: S-EPMC12926523 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature