Unavailability of experimental 3D structural data on protein folding dynamics and necessity for a new generation of structure prediction methods in this context.

ABSTRACT:

Motivation

Protein folding is a dynamic process during which a protein's amino acid sequence undergoes a series of 3D conformational changes en route to reaching a native 3D structure; these conformations are called folding intermediates. While data on native 3D structures are abundant, data on 3D structures of non-native intermediates remain sparse, due to limitations of current technologies for experimental determination of 3D structures. Yet, analyzing folding intermediates is crucial for understanding folding dynamics and misfolding-related diseases. Hence, we search the literature for available (experimentally and computationally obtained) 3D structural data on folding intermediates, organizing the data in a centralized resource. Also, we assess whether existing methods, desig

SUBMITTER: Wells A 

PROVIDER: S-EPMC12926781 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature