Toward Rapid Actinium-225 Purification via Membrane Adsorbers with Covalently Tethered Diglycolamide Ligands.

ABSTRACT: Extractive diglycolamide (DGA) resins are used in several state-of-the-art techniques for purifying ²²⁵Ac, a promising radiometal for targeted alpha therapy. Unfortunately, separation processes that rely on resins are often limited to slow flow rates, high elution volumes, and long processing times. Membrane adsorbers functionalized with DGA ligands are an alternative separation material that may overcome these challenges. This work presents (1) the synthesis of an aminated tetrahexyldiglycolamide ligand, (2) the covalent tethering of the ligand to electrospun poly(vinylbenzyl chloride) fiber mats, and (3) the adsorption and desorption of La(III) and ²²⁵Ac. Chemical and physical characterization supports the covalent tethering of the ligand to the fiber mat, as well a

SUBMITTER: Radhakrishnan SK 

PROVIDER: S-EPMC12926944 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature