Renal dysfunction and outcomes in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: an individual participant data meta-analysis.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) cause right ventricular dysfunction with extrapulmonary sequelae including renal dysfunction. We sought to characterise renal dysfunction in PAH and CTEPH and to assess the effect of pulmonary hypertension treatment on renal function.

Methods

We performed an individual participant data meta-analysis of 6694 participants from 18 phase III randomised clinical trials of pulmonary hypertension therapies. We calculated estimated glomerular filtration rate (eGFR) using the race-agnostic 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.

Results

The mean±sd age was 49.6±15.5 years, 78% were female and 58% had idiopathic PAH. A total of 907 (13.5%

SUBMITTER: Meservey A 

PROVIDER: S-EPMC12926957 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature