Four Decades of Inquiry Into the Genetic Bases of Specific Reading Disability.

ABSTRACT:

Purpose

This study investigated the genetic bases of specific reading disability (SRD) by systematically cataloging candidate genes reported as associated with SRD and reading-related processes over the last 4 decades and analyzing their evolutionary conservation, developmental expression patterns, and functional networks to address significant knowledge gaps in understanding the genetic architecture of reading (dis)ability.

Method

Through a comprehensive literature review, we identified 175 putative SRD (and reading-related processes) candidate genes (hereafter, SRD genes). Using bioinformatic approaches, we analyzed their evolutionary conservation across species, examined their expression patterns in developmental and single-cell transcriptome data sets from the Allen Brai

SUBMITTER: Dobrynin P 

PROVIDER: S-EPMC12926963 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature