Sensory and Sympathetic Nerve Localization in Mouse Temporomandibular Joint and Knee Joint Neuro-Musculoskeletal Tissues.

ABSTRACT:

Objective

Sympathetic-sensory coupling is increasingly implicated in joint homeostasis and disease. Towards the long-term goal of deciphering its role in temporomandibular disorders (TMDs), we characterised the spatial relationships of sympathetic and sensory nerves and their receptors in the mouse temporomandibular joint (TMJ) and trigeminal ganglion (TG), using the knee joint for comparison.

Materials and methods

RNAscope was used for localisation of sympathetic nerve markers tyrosine hydroxylase (Th) and adrenergic receptor alpha 2a (Adrα2a); and brain-derived neurotrophic factor (Bdnf) and its receptor neurotrophic receptor tyrosine kinase 2 (Ntrk2) that stimulate sympathetic nerve growth. Sensory marker calcitonin gene-related peptide (CGRP) was detected through immunof

SUBMITTER: Ye Q 

PROVIDER: S-EPMC12927137 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature