Identification of differentially expressed genes associated with tracheal injury recovery in a rabbit model of septic shock.

ABSTRACT:

Background

Sepsis is a syndrome caused by the host's inflammatory response to an infection with an unknown mechanism. This study aimed to identify differentially expressed genes (DEGs) potentially involved in the development and recovery of tracheal injury from septic shock.

Methods

Nine New Zealand white rabbits were randomized to control (CON), septic shock model (SS), and septic shock norepinephrine treatment (SSNE) groups (each group n = 3). The SS and SSNE groups were injected with lipopolysaccharide to induce septic shock. The SSNE group was administered Ringer lactate with norepinephrine to maintain normal blood pressure. All animals underwent cuffed endotracheal intubation for 2 h. The injured tracheal segment was harvested. RNA sequencing was performed to identify t

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12927218 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature