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HNF4A P2 isoform alleviates kidney fibrosis by inhibiting dedifferentiation of proximal tubular cells through JAG1/NOTCH signaling.
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ABSTRACT:
SUBMITTER: Jiang G
PROVIDER: S-EPMC12927263 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
HNF4A P2 isoform alleviates kidney fibrosis by inhibiting dedifferentiation of proximal tubular cells through JAG1/NOTCH signaling.
Cellular & molecular biology letters 20260120 1
BACKGROUND: Tubulointerstitial fibrosis is a critical and irreversible process of chronic kidney disease. Dedifferentiated proximal tubular cells (PTCs) after injury are important for tubulointerstitial fibrosis. Hepatocyte nuclear factor 4 alpha (HNF4A) is the main regulatory factor for PTC differentiation. However, its role in PTC dedifferentiation and kidney fibrosis remains unclear. METHODS: To investigate the role of HNF4A in kidney fibrosis, bioinformatics analysis and in vivo models were ...[more]