Elevated serum peroxiredoxin 1 is a biomarker of multiorgan failure in ARDS.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome with high morbidity and mortality. Despite advances in understanding its pathophysiology, definitive biomarkers for ARDS disease stratification and management remain lacking. This study evaluated the utility of circulating PRDX1 in predicting 28-day mortality in ARDS patients.

Methods

A retrospective cohort study was conducted at Third Xiangya Hospital, enrolling 90 ARDS patients. Serum PRDX1 levels and clinical data were collected and compared with those from healthy volunteers and non-ARDS pneumonia patients to examine its alterations in ARDS patients; multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were then employed to assess the prognost

SUBMITTER: Jiang G 

PROVIDER: S-EPMC12927329 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature