Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling.

ABSTRACT: 3D in vitro tissue and disease models have emerged as an important tool for diagnostic and therapeutic screenings, as they offer a closer approximation toward native environments than traditional 2D cell culture. Kidney disease modeling in particular has progressed to using induced pluripotent stem cells (iPSCs) and microfluidic platforms to replicate the complex microenvironment of the kidney. However, current models lack mature tissue development, scalability, tunability, and spatial organization. In this study, a fully synthetic, 3D kidney disease platform that addresses these challenges is presented. This model comprises a compartmentalized poly (ethylene glycol) (PEG)-based hydrogel matrix with anisotropic PEG-based microgels. This multiphasic hydrogel system provides control over spa

SUBMITTER: Mohl N 

PROVIDER: S-EPMC12927530 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature