Persistence and spread of fluconazole-resistant <i>Candida parapsilosis</i> clinical isolates associated with increased <i>ERG11</i> copies in Qatar.

ABSTRACT: Candida parapsilosis is one of the most common species associated with candidemia infections globally. Recently, the emergence of fluconazole-resistant (FLU-R) C. parapsilosis has become a significant global public health concern. In this study, we investigated the genomic epidemiology and potential mechanisms of antifungal resistance among 51 hospital isolates in Qatar, of which 18 were FLU-R. Whole-genome SNP analysis revealed the presence of five major genetic clusters and evidence for cross-hospital transmission within clusters I, II and III. Cluster I had 21 isolates, including all 18 FLU-R isolates collected from 2015 to 2021. These 18 FLU-R isolates had no missense variants known to be associated with azole resistance in loci such as ERG11, ERG6 and TAC1;

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12927641 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature