Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles.

ABSTRACT:

Background

Mitochondrial ATP production, essential for cardiomyocyte function, is regulated by mitochondrial Ca²⁺ (mtCa²⁺). The primary route for mtCa²⁺ influx is the mitochondrial calcium uniporter complex. The mitochondrial calcium uniporter complex subunit MICU (mitochondrial calcium uptake) 1 limits mtCa²⁺ uptake, preventing mtCa²⁺ overload. Although elevated mtCa²⁺ has been observed in multiple diseases including heart failure, its effects on heart function remain elusive.

Methods

To investigate the impact of elevated mtCa²⁺ in adult hearts, we generated a mouse model with cardiomyocyte-specific tamoxifen-inducible Micu1 deletion (Micu1^cKO). Cardiac function was

SUBMITTER: Pakkiriswami S 

PROVIDER: S-EPMC12927646 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature