Neutrophil gelatinase-associated lipocalin for urinary tract infection and pyelonephritis: a systematic review.

ABSTRACT:

Background

The sensitivity and specificity of the leukocyte esterase test are relatively low for a screening test for urinary tract infection (UTI). More accurate tests could reduce both overtreatment and missed cases. This study aimed to determine whether neutrophil gelatinase-associated lipocalin (NGAL) can replace leukocyte esterase in the diagnosis of UTI and/or whether NGAL accurately identifies children with acute pyelonephritis.

Methods

Data sources-MEDLINE and EMBASE. We only considered published studies that evaluated the results of an index test (NGAL) against the results of urine culture (for UTI) or against the results of dimercaptosuccinic acid (for acute pyelonephritis) in children aged 0 to 18 years. Two authors independently applied the selection criteria to

SUBMITTER: Shaikh K 

PROVIDER: S-EPMC12927658 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature