Daily intermittent fasting is an effective multiscale treatment in preclinical models of absence epilepsy.

ABSTRACT:

Objective

Absence epilepsy is characterized by brief but frequent seizures with loss of consciousness. Existing treatments, which come with heavy side effects, are only partially effective and do not address the associated comorbidities, including cognitive and social deficits. A tripartite link between seizures, cognitive deficits, and diet has been established. Intermittent fasting (IF) is a regime where daily periods of fasting are alternated with periods of food intake. To date, the effects of IF on infantile epilepsy have not been addressed. We evaluated the therapeutic potential of a daily, 1-month protocol of IF on an established model of generalized absence epilepsy, the Grm7^AAA knock-in mouse.

Methods

To assess the effects of IF in mice, we combined elect

SUBMITTER: Rulhe C 

PROVIDER: S-EPMC12927692 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature