Comparative Genomic and Transcriptomic Analysis Reveals Why Paenarthrobacter Strains Are Specialists in the Degradation of the Fungicide Iprodione.

ABSTRACT: Paenarthrobacters degrade the fungicide iprodione through a pathway involving an amidase (IpaH), a deacetylase (DdaH) and a hydrolase (DuaH). We aimed to elucidate the mechanisms of this catabolic specialisation and its evolution in Paenarthrobacters. Two new iprodione-degrading Paenarthrobacter strains TA1.8 and C1 were sequenced, and their genomes were analysed comparatively to the iprodione-degrading Paenarthrobacter strains YJN-5 and YJN-D. We noted different gene organisation motifs amongst strains, suggesting different stages of pathway evolution in the studied strains depending on their prior exposure to iprodione. Strains derived from soils exposed to iprodione (TA1.8, YJN-5 and YJN-D) carry multiple copies of ipaH, ddaH and duaH. Conversely, strain C1, isolated from a pristine soi

SUBMITTER: Michelioudakis V 

PROVIDER: S-EPMC12927932 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature