Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists Following Bariatric Surgery: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Glucagon-like peptide-1 receptor agonists (GLP-1RA) have demonstrated promising effects in promoting weight loss and improving metabolic markers. However, their effectiveness post-bariatric surgery remains uncertain.

Methods

PubMed, Cochrane CENTRAL, and Scopus were queried through March 2025 for randomised controlled trials comparing GLP-1RA to placebo in post-bariatric surgery patients. Outcomes included weight loss, BMI, total cholesterol, triglycerides, fasting blood glucose, blood pressure, HbA1c, and adverse events. Random-effects models were used to calculate standardised mean differences (SMDs), weighted mean differences (WMDs), and risk ratios (RRs).

Results

Six trials (n = 401) were included. GLP-1RA significantly reduced weight (SMD: -5.96 kg [95

SUBMITTER: Bilal AR 

PROVIDER: S-EPMC12928090 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature