Whole blood gene expression moderates associations between AD biomarkers and cognitive decline in cognitively unimpaired older adults.

ABSTRACT:

Introduction

Early biological pathways explaining the risk for Alzheimer's disease (AD)-related cognitive decline remain poorly understood.

Methods

Using linear mixed-effects models, we investigated whether whole blood gene expression (RNA sequencing) moderates the relationship between AD biomarkers measured by amyloid beta (Aβ) and tau-PET (positron emission tomography) imaging and longitudinal cognition in 770 cognitively unimpaired older adults (Age_mean = 71.3, 62% female) from Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) (A4/LEARN).

Results

We identified protective and AD risk-related gene expression signatures on the autosome and X chromosome. Six genes (n_genes

SUBMITTER: Klinger HM 

PROVIDER: S-EPMC12928093 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature