Comparing Mean-anchored Generalized Linear Binning with Established Methods to Quantify Xenon-129 Ventilation Defect Percentage.

ABSTRACT:

Rationale and objectives

Hyperpolarized xenon-129 (¹²⁹Xe) MRI is an established, sensitive method to assess ventilation but lacks a standardized ventilation defect quantification. We introduce mean-anchored generalized linear binning (Mean_GLB, GLB) to calculate ventilation defect percentage (VDP), benchmarking its performance against reader-segmented VDP (Reader) and five widely-used automated VDP calculation methods.

Materials and methods

¹²⁹Xe images were acquired from 38 people with cystic fibrosis (CF) and 25 age-matched healthy controls (HCs) using 2D-spiral sequence. Flexible chest coil-induced inhomogeneities were mitigated using both N4- or a flip-angle (FA)-based bias correction. VDP was quantified using Reader, Hierarchical and Adap

SUBMITTER: Hussain R 

PROVIDER: S-EPMC12928158 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature