Genomic Analysis of Doxycycline Resistance-Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum.

ABSTRACT: We inspected 16S rRNA sequences of 784 publicly available Treponema pallidum subspecies pallidum genomes and 17 new T. pallidum subsp. pallidum genomes from Canada for putative mutations associated with doxycycline resistance. Variants were detected in 9 non-Canada genomes. These findings establish a global genomic baseline for monitoring doxycycline resistance in syphilis.

SUBMITTER: Long GS 

PROVIDER: S-EPMC12928234 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature