Progression of Neuroinflammation Is Associated With Clinical Prognosis of Patients Undergoing Intravenous Thrombolysis.

ABSTRACT:

Background

Recent research has shown that neuroinflammation progresses rapidly within a few hours after stroke; however, the relationship between its progression and clinical outcomes remains unclear. Therefore, this study aimed to investigate the effect of neuroinflammation, measured by serum GFAP (glial fibrillary acidic protein), on patient outcomes, as well as the influence of baseline peripheral inflammation on the progression of neuroinflammation.

Methods

This prospective cohort study enrolled patients with acute ischemic stroke who received intravenous thrombolysis (IVT) between September 2016 and April 2023 across 16 centers in China. Serum GFAP levels were measured before (baseline, within 4.5 hours of onset) and at 24 hours after IVT. GFAP changes were determined b

SUBMITTER: Qu Y 

PROVIDER: S-EPMC12928816 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature