Laboratory Abnormalities Associated With the Use of Preventive Pharmacological Therapy for Urinary Stone Disease.

ABSTRACT:

Objective

To define the risk of laboratory abnormalities associated with commonly prescribed medications in the context of urinary stone disease (USD).

Materials and methods

We used the Veterans Health Administration Corporate Warehouse to identify adults ≥ 18 years with an index episode of USD. The development of laboratory abnormalities for those ever versus never on preventive pharmacological therapy was then compared using separate Cox proportional hazards regression models for each laboratory abnormality-drug class combination, adjusting for baseline patient characteristics and time-varying medication use over the study period. To provide a sense for absolute risk, we then used the models to estimate 2-year predicted probabilities of developing a laboratory abnormality

SUBMITTER: Lee MS 

PROVIDER: S-EPMC12928847 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature