Effectiveness and Safety of COVID-19 Vaccination in Patients With Heart Failure: A Nationwide Retrospective Cohort Study.

ABSTRACT:

Background and objectives

We aimed to evaluate the efficacy and safety of coronavirus disease 2019 (COVID-19) vaccination in patients with heart failure (HF) using national databases.

Methods

We retrospectively analyzed the data from the Korean nationwide COVID-19 cohort, including patients with HF from February 2021 to June 2022. The study population was divided into the vaccinated (≥2 doses) and unvaccinated (≤1 dose) groups. Clinical outcomes assessed included hospitalization for HF, COVID-19-related events, and cardiovascular complications. Patients were matched by age, sex, and comorbidities, and were followed up for up to 15 months to assess vaccination-associated risks.

Results

We included 651,127 patients with HF (mean age 69.5 years; 50.2% male), of whom 112,

SUBMITTER: Chun KH 

PROVIDER: S-EPMC12929037 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature