Dataset Information
Prevalence of substances with OATP1B1 inhibitory properties in individual case safety reports of suspected statin-associated myopathy - an analysis of Swiss pharmacovigilance data.
Ontology highlight
ABSTRACT:
SUBMITTER: Stauble CK
PROVIDER: S-EPMC12929307 | biostudies-literature | 2026 Feb
REPOSITORIES: biostudies-literature
Publications
Prevalence of substances with OATP1B1 inhibitory properties in individual case safety reports of suspected statin-associated myopathy - an analysis of Swiss pharmacovigilance data.
European journal of clinical pharmacology 20260224 3
PURPOSE: Statin associated musculoskeletal symptoms (SAMS) are common adverse drug reactions reported by 20% of statin users and are assumed to be dose dependent. The organic anion transporting polypeptide 1B1 (OATP1B1), a hepatocellular uptake transporter, modulates the systemic exposure of statins. The concurrent use of OATP1B1 inhibitors can increase systemic statin exposure and thus increase the risk of SAMS. METHODS: Individual case safety reports (ICSRs) of suspected adverse drug reactions ...[more]
